GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs10918270 | 1 | rs10737521 | chr1:161932193 | ATF6 | chr1:161736084-161932960:+ | -0.08 | -3.48 | 0.000513 | Parkinson's disease (age of onset) |
| BRCA | cis | rs282544 | 1 | rs10737958 | chr5:50023374 | PARP8 | chr5:49961733-50138169:+ | -0.13 | -3.59 | 0.000346 | Myopia (pathological) |
| BRCA | cis | rs6477998 | 1 | rs10739388 | chr9:115977175 | CDC26 | chr9:116029290-116037869:- | -0.27 | -7.67 | 3.82E-14 | Hematology traits |
| BRCA | cis | rs9783347 | 1 | rs10741741 | chr11:18342081 | GTF2H1 | chr11:18343816-18388590:+ | -0.31 | -8.32 | 2.66E-16 | Pancreatic cancer |
| BRCA | cis | rs9783347 | 1 | rs10741742 | chr11:18342160 | GTF2H1 | chr11:18343816-18388590:+ | 0.31 | 8.3 | 3.04E-16 | Pancreatic cancer |
| BRCA | cis | rs10160456 | 1 | rs10742172 | chr11:27314297 | LGR4 | chr11:27387510-27494334:- | 0.14 | 4.11 | 4.25E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10742174 | chr11:27332291 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.23 | 2.49E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10742175 | chr11:27333897 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.23 | 2.49E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10770857 | 1 | rs10743422 | chr12:8703479 | CLEC4D | chr12:8666136-8674958:+ | 0.12 | 4.4 | 1.18E-5 | Response to radiotherapy in prostate cancer (overall toxicity) |
| BRCA | cis | rs10770857 | 1 | rs10743424 | chr12:8704358 | CLEC4D | chr12:8666136-8674958:+ | 0.12 | 4.36 | 1.44E-5 | Response to radiotherapy in prostate cancer (overall toxicity) |
| BRCA | cis | rs10770857 | 1 | rs10743425 | chr12:8705164 | CLEC4D | chr12:8666136-8674958:+ | 0.12 | 4.39 | 1.26E-5 | Response to radiotherapy in prostate cancer (overall toxicity) |
| BRCA | cis | rs718314 | 1 | rs10743579 | chr12:26461145 | BHLHE41 | chr12:26272961-26278003:- | 0.13 | 3.42 | 0.000649 | Waist-hip ratio;Renal cell carcinoma |
| BRCA | cis | rs7953704 | 1 | rs10744177 | chr12:122630009 | LRRC43 | chr12:122652266-122688017:+ | 0.18 | 5.02 | 5.93E-7 | Urate levels |
| BRCA | cis | rs7953704 | 1 | rs10744335 | chr12:122612146 | LRRC43 | chr12:122652266-122688017:+ | 0.16 | 4.51 | 7.04E-6 | Urate levels |
| BRCA | cis | rs703842 | 1 | rs10747783 | chr12:58176614 | B4GALNT1 | chr12:58019551-58026985:- | 0.13 | 3.65 | 0.000273 | Multiple sclerosis |